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A Brief Overview
Dr. Wolpaw's laboratory is seeking a Research Technician III for his lab focused on using animal models of childhood cancer. The successful applicant will have a BA or BS in biology, chemistry, or a related field and prior experience working with laboratory animals.

Dr. Wolpaw's laboratory seeks to develop an understanding of how tumor heterogeneity and epigenetics impact inflammatory signaling and immunotherapy responses in pediatric solid tumors with a goal of developing more efficacious, less toxic therapies to treat these devastating diseases. The applicant will work primarily on in vivo projects to characterize new immunocompetent models of neuroblastoma lineage heterogeneity (using ChIP-seq and single-cell RNA sequencing) and to determine how lineage heterogeneity impacts response to multiple different therapies. They will also contribute to other work going on in the lab on using CRISPR-Cas9 screens to uncover the transcriptional regulation of innate immune sensing pathways in neuroblastoma and characterizing how activation of inflammatory signaling in neuroblastoma cells impact immune surveillance and immunotherapy responses. This work builds on our published study in PNAS (https://www.pnas.org/doi/10.1073/pnas.2102358119) and is funded by grants from the Department of Defense and the NIH.

What you will do

• Performs routine tests / experiments under the direction of principal investigator, supervisor or other designee
• Performs research procedures on experimental samples as directed
• Records and checks experiments/ results for completeness and accuracy
• Performs calculations and maintains appropriate log and lab notebooks
• Performs tasks that require familiarity with fundamental techniques and lab equipment
• May assist with planning specific research protocols and procedures
• Maintains office, lab area, solutions, reagents, supplies and equipment, disposes of specimens, media and other materials (using appropriate procedures)
• Assists in care and maintenance of lab equipment
• May coordinate schedules of tests and procedures
• Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
• Records results, organizes data and maintains lab notebook in an organized manner
• Compiles and helps analyze data, prepares charts, graphs, and results of studies as directed
• Conducts literary searches as directed
• Handle and work with laboratory Animals

Education Qualifications

• High School Diploma / GED Required
• Associate's Degree Preferred
• Bachelor's Degree Preferred

Experience Qualifications

• At least one (1) year of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Required

Skills and Abilities

• Intermediate understanding of lab procedures, protocols, and equipment.
• Basic exposure to lab specific experiments / techniques and scientific analysis
• Excellent verbal and written communications skills
• Excellent organizational skills
• Solid critical thinking / problem-solving skills
• Solid analytical skills
• Handling laboratory animals

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine. Learn more.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

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